Lep-KO

Nomenclature

B6;129S-Leptm1Smoc

Cat. NO.

NM-KO-00034

Strain State

Repository Live

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Gene Summary

Gene Symbol
Lep

Synonyms

ob; obese

NCBI ID

16846

MGI ID

104663

Ensembl ID

ENSMUSG00000059201

Pubmed

Lep

Human Ortholog

LEP

Model Description

Exon 2 was replaced by Neo cassette.
Research Application：Insulin resistance,obesity,and type 2 diabetes etc.

Validation Data

image.png

Fig1. Body weight and Blood glucose monitoring of ob/ob mice.

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Fig2. Evaluation of Oral glucose tolerance test (OGTT) of female ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. **, P ≤ 0.01.

Note. The tested ob/ob and C57BL/6 mice were 6 weeks old.

image.png


Fig3. Detection of insulin levels in serum by ELISA. 

Abbr. Hom, homozygous; HE, heterozygous; WT, wild type.

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old.

image.png

Fig4. H&E staining of the subcutaneous adipose tissue (SAT) in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 20.

image.png

Fig5. Representative pictures of pancreas in ob/ob mice. 

These results suggested the inflammatory cell infiltration of the pancreas in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 10.

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