hCSF1R(2)
Nomenclature
C57BL/6JSmo-Csf1rtm3(hCSF1R)Smoc
Cat. NO.
NM-HU-190074
Strain State
Embryo Cryopreservation
Gene Summary
Gene Symbol
CSF1R
Model Description
Validation Data
Fig1. Detection of CSF1R(2) expression in spleen by RT-PCR. Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.
Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008，BMS，phase II）
Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.
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