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U-GEMMs

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Gene Editing Technology

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Humanization

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Surgery & Preconditioning

Surgery

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Supporting Solutions

Colony Management

Cryopreservation and Cryorecovery

Housing and Management

Genotyping Analysis

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Auxiliary Apparatuses

e-BLOT WB Imaging System
Pre-clinical CRO Services
Oncology Drug Efficacy Evaluation Platform

Syngeneic Models

Genetically Modified Tumor Mouse Models

GMM models of cancer

GMM-derived tumor allograft models

Xenograft mouse models

CDX

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Human Immune System Reconstituted Models

HuPBMC

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Metabolism Disease Evaluation Platform

Obesity/Diabetes Models

MASH Model

Other metabolic disease models

Hyperuricemia Models

Atherosclerosis Models

Phenylketonuria Models

Humanized Metabolic Research Model

Inflammation Disease Evaluation Platform

Inflammation/Autoimmune Disease Model

Psoriasis model

Atopic Dermatitis Model

Delayed-type hypersensitivity Model

Androgenetic Alopecia Model

Asthma Model

Pulmonary Fibrosis Model

Rheumatoid Arthritis Model

Osteoarthritis Model

Systemic Lupus Erythematosus Model

Sepsis Model

Multiple Sclerosis Model

Graft-Versus-Host Disease Model

Inflammatory Bowel Disease Model

Chronic Kidney Disease Model

Others immune-mediated inflammatory diseases model

Neurological Disease Evaluation Platform

Neurological Disease Models

Parkinson's Disease Model

Alzheimer's Disease Model

Depression Model

Pain Model

Cerebrovascular Diseases Model

Intracranial Tumor

Amyotrophic Lateral Sclerosis Model

Other Neurological Disease Models

Behavioral Research Platform

Cell Lines Service Platform

Off-the-shelf cell lines

iPSC-mediated Disease Models

Cell Line Customization Services

Ex vivo & In vitro Evaluation Service Platform

Ex vivo Pharmacodynamic Evaluation Service

In vitro Pharmacodynamic Evaluation Service

Toxicology/Pathology Service Platform

Non-GLP Toxicology Evaluation Platform

Pathology Service Platform
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U-GEMMs

The establishment of U-GEMM (yoUr Genetically Engineered Mouse Model) repository containing 6,000+ “off-shelf” proprietary sets the stage of entry into new possibilities in gene function, drug screening, and human disease research.

Mouse	Cdkn2a/Cdkn2b-KO(p15/p16/p19-KO) Strain Name：C57BL/6JSmo-Cdkn2a^emCdkn2b^em¹^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-241617
Mouse	Cdkn2aip-Flox Strain Name：C57BL/6Smoc-Cdkn2aip^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Mouse	Cdkn2Aip-KO Strain Name：C57BL/6Smoc-Cdkn2Aip^em1Smoc Strain State：Developing \| Cat. NO.：TBD
Mouse	Cdkn2aipnl-Flox Strain Name：C57BL/6Smoc-Cdkn2aipnl^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Mouse	Cdkn2Aipnl-KO Strain Name：C57BL/6Smoc-Cdkn2Aipnl^em1Smoc Strain State：Developing \| Cat. NO.：TBD
Mouse	Cdkn2b-Flox(p15-Flox) Strain Name：C57BL/6JSmo-Cdkn2b^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-2115067
Mouse	Cdkn2b-KO(p15-KO) Strain Name：C57BL/6JSmo-Cdkn2B^em1Smoc Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KO-190621 Research Application：This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
Mouse	Cdkn2c-Flox Strain Name：C57BL/6JSmo-Cdkn2c^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-205110 Disease Connection：medulloblastoma
Mouse	Cdkn2C-KO Strain Name：C57BL/6JSmo-Cdkn2C^em1Smoc Strain State：Embryo Cryopreservation \| Cat. NO.：NM-KO-2114003 Disease Connection：medulloblastoma
Mouse	Cdkn2d-Flox Strain Name：C57BL/6Smoc-Cdkn2d^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD

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