Rag2-KO/hTROP2
Nomenclature
C57BL/6JSmo-Rag2em2Tacstd2tm(hTACSTD2)Smoc
Cat. NO.
NM-HU-234872
Strain State
Embryo Cryopreservation
Model Description
Validation Data
Fig.1 Subcutaneous xenograft tumor growth of NCI-N87 in Rag2-KO/hTROP2 mouse model.
Fig 2. Body weight change and means of body weight of Rag2-KO/hTROP2 mouse model after tumor inoculation.
Fig.3 Tumor volume of Sacituzumab govitecan-treated Rag2-KO/hTROP2 mice.
Female, 13-week-old homozygous mice were subcutaneously inoculated in the right flank with NCI-N87 tumor cells (1×10⁷ cells in 50% Matrigel) to establish tumor growth. Randomization began when the mean tumor volume reached approximately 200-250 mm³ (about one week post-inoculation). Mice were randomly assigned to three treatment groups (n = 8 per group): Group 1 received saline, Group 2 received Sacituzumab govitecan at 0.25 mg/mouse twice weekly, and Group 3 received Sacituzumab govitecan at 0.5 mg/mouse once weekly. All treatments were administered for four weeks starting from the day of grouping. Data are presented as mean ± SEM.
Fig.4 Body weight change of NCI-N87-bearing Rag2-KO/hTROP2 mice under the treatment of saline or Sacituzumab govitecan.
Female, 13-week-old homozygous mice were subcutaneously inoculated in the right flank with NCI-N87 tumor cells (1×10⁷ cells in 50% Matrigel) to establish tumor growth. Randomization began when the mean tumor volume reached approximately 200-250 mm³ (about one week post-inoculation). Mice were randomly assigned to three treatment groups (n = 8 per group): Group 1 received saline, Group 2 received Sacituzumab govitecan at 0.25 mg/mouse twice weekly, and Group 3 received Sacituzumab govitecan at 0.5 mg/mouse once weekly. All treatments were administered for four weeks starting from the day of grouping. Data are presented as mean ± SEM.
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