hCD40(BALB/c)

Nomenclature

BALB/cJSmo-Cd40tm1(hCD40)/Smoc

Cat. NO.

NM-HU-2000047

Strain State

Embryo Cryopreservation

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Gene Summary

Gene Symbol
CD40

Model Description

The endogenous mouse Cd40 gene was replaced by human CD40 gene.
Research Application:Immunotherapy,drug screening

Validation Data

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Fig1. Analysis of hCD40 expression in PBMC in the hCD40 mice by FACS. hCD40 was expressed on B cells in PB.

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Fig2. Analysis of hCD40 expression on splenic B cells by FACS. hCD40 was expressed on the B cells in the spleen.

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Fig3. Analysis of human CD40 expression on splenic DCs and macrophages by FACS . The homozygous KI mouse expresses human CD40 on DCs and macrophages.(Provided by CrownBio)



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