hCD19

Nomenclature

C57BL/6JSmo-Cd19tm1(hCD19) Smoc

Cat. NO.

NM-HU-00110

Strain State

Repository Live

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Gene Summary

Gene Symbol
CD19

Synonyms

AW495831

NCBI ID

12478

MGI ID

88319

Ensembl ID

ENSMUSG00000030724

Pubmed

CD19

Human Ortholog

CD19

Model Description

The endogenous mouse Cd19 gene was replaced by human CD19 gene .
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

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Fig.1 Expression characterization of hCD19 on B cells in blood in hCD19 knockin mice.

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Fig.2 Expression characterization of hCD19 on B cells in spleen in hCD19 knockin mice.

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Fig.3 Expression characterization of hCD19 on B cells in thymus in hCD19 knockin mice.

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Fig.4 Body weight and ratios of spleen, thymus and MLN to body weight of 8-week-old hCD19 knockin mice. (n=6 for all groups, Mean±SEM, Unpaired t-test, *P<0.05, **P<0.01).

Abbr. HO, homozygous; WT, wild type; MLN, mesenteric lymph nodes.

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Table 1. Blood routine examination of hCD19 knockin mice. Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.

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Table 2. Biochemical test of serum from hCD19 knockin mice. Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.

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Fig.5 Blood biochemical detection of 8-week-old hCD19 knockin mice. (n=6 for all groups, Mean±SEM).

Abbr. HO, homozygous; WT, wild type.

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Fig.6 Detection of myeloid cell subsets in the blood of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.7 Detection of lymphocyte subsets in the blood of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.8 Detection of myeloid cell subsets in the spleen of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.9 Detection of lymphocyte subsets in the spleen of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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