HLA-A2.1/B2M
Nomenclature
C57BL/6JSmo-B2mtm1(hB2M-linker-HLA-A*0201/H2-D1)Smoc
Cat. NO.
NM-HU-241353
Strain State
Repository Live
Gene Summary
Gene Symbol
B2M
Model Description
Validation Data
Fig.1 Detection of hB2M expression in Blood in WT C57BL 6 and HO HLA-A2.1/B2M mice.
Fig.2 Detection of HLA-ABC expression in Blood in WT C57BL/6 and HO HLA-A2.1/B2M mice.
Fig.3 Detection of vaccine-induced immune responses in HLA-A2.1/B2M mice by ELISpot assay.
Under peptide pool stimulation, both WT mice and HLA-A2.1/B2M mice mounted cellular immune responses, with the latter exhibiting stronger responses. Upon stimulation with NY-ESO-1157-165, WT mice showed no response, whereas HLA-A2.1/B2M mice generated a robust cellular immune response, demonstrating that this mouse model can effectively present the hHLA-A2.1-restricted dominant epitope NY-ESO-1157-165.
Fig.4 T-cell intracellular cytokine staining (ICS) assays.
Upon stimulation with the hHLA-A2.1-restricted dominant epitope NY-ESO-1157-165, only HLA-A2.1/B2M mice generated a large number of IFN-γ-positive CD8 T cells.
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