hSSTR2
Nomenclature
C57BL/6JSmo-Sstr2tm1(hSSTR2)Smoc
Cat. NO.
NM-HU-241884
Strain State
Repository Live
Gene Summary
Gene Symbol
Sstr2
Model Description
Validation Data
Fig.1 Detection of SSTR2 expression in cerebrum by RT-PCR. Mouse Sstr2 mRNA (216 bp) was detectable only in wild-type C57BL/6 mice. Human SSTR2 mRNA (153 bp) was detectable only in homozygous hSSTR2 knockin mice but not in wild-type mice. Cerebrum and pancreas RNA was extracted from 8-week-old male wild-type C57BL/6 (WT)(n=2) and homozygous hSSTR2 knockin mice (HO) (n=2) , then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of SSTR2 expression in hSSTR2 mice by WB. SSTR2 was detectable in cerebrum, pancreas and kidney from both WT C57BL/6 and HO hSSTR2 mice , as the antibody was cross-reactived between human and mouse SSTR2. The cerebrum, pancreas and kidney tissue lysates were collected from 6-week-old male wild-type C57BL/6 mice and 6-week-old male homozygous hSSTR2 mice, and then analyzed by western blot with anti-SSTR2 antibody.
Abbr. HO, homozygous; WT, wild type; PC, positive control, MCF-7 cells.
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