Il6-2A-DTR-2A-EGFP
Nomenclature
C57BL/6JSmo-Il6em1(P2A-DTR-T2A-EGFP-WPRE-pA)Smoc
Cat. NO.
NM-KI-242149
Strain State
Sperm cryopreservation
Gene Summary
Gene Symbol
IL6
Model Description
Validation Data
Fig.1 Detection of EGFP expression in blood macrophages of Il6-2A-DTR-2A-EGFP mice by FACS.
Il6-2A-DTR-2A-EGFP mice that received an intraperitoneal dose of LPS (5 mg/kg) and were sacrificed 2 h later exhibited a pronounced increase of EGFP+ signals in blood (n=2, male, 6 weeks old).
Abbr. HE, heterozygous; WT, wild type.
Fig.2 Detection of EGFP expression in bone marrow macrophages of Il6-2A-DTR-2A-EGFP mice by FACS.
Il6-2A-DTR-2A-EGFP mice that received an intraperitoneal dose of LPS (5 mg/kg) and were sacrificed 2 h later exhibited a pronounced increase of EGFP+ signals in bone marrow (n=2, male, 6 weeks old).
Abbr. HE, heterozygous; WT, wild type.
Fig.3 Detection of EGFP expression in spleen macrophages of Il6-2A-DTR-2A-EGFP mice by FACS.
Il6-2A-DTR-2A-EGFP mice that received an intraperitoneal dose of LPS (5 mg/kg) and were sacrificed 2 h later exhibited a pronounced increase of EGFP+ signals in spleen (n=2, male, 6 weeks old).
Abbr. HE, heterozygous; WT, wild type.
Fig.4 Detection of EGFP expression in liver macrophages of Il6-2A-DTR-2A-EGFP mice by FACS.
Il6-2A-DTR-2A-EGFP mice that received an intraperitoneal dose of LPS (5 mg/kg) and were sacrificed 2 h later exhibited a pronounced increase of EGFP+ signals in liver (n=2, male, 6 weeks old).
Abbr. HE, heterozygous; WT, wild type.
You may also like
Workshop：Progress and Advances in Preclinical immuno-Oncology Research
SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.
Learn moreShanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreCustomizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
Learn more
