hS100A9

Nomenclature

C57BL/6JSmo-S100a9tm1(hS100A9)Smoc

Cat. NO.

NM-HU-242497

Strain State

Repository Live

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Gene Summary

Gene Symbol
S100a9

Model Description

The endogenous mouse S100a9 gene was replaced by human S100A9 gene.

Validation Data

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Fig.1 Detection of S100A9 expression on neutrophil in spleen of WT C57BL/6 mice and HO hS100A9 mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 15 weeks old) and homozygous hS100A9 humanized mice (male, famale, 15 weeks old), and analyzed by flow cytometry with anti-mS100A9 and anti-hS100A9. hS100A9 was exclusively detectable in hS100A9 humanized mice but not in wild-type mice. hS100A9 was exclusively detectable on neutrophil in hS100A9 humanized mice, whereas mS100A9 was exclusively detectable on neutrophil in wild-type C57BL/6 mice.


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