pAlb-hLPA-3’UTR-pA-TG/Apoe-KO
Nomenclature
C57BL/6JSmo-Tgtn(pAlb-hLPA-3’UTR-pA)1Apoeem5Smoc
Cat. NO.
NM-XA-242591
Strain State
Embryo Cryopreservation
Model Description
Validation Data
Fig.1 Phenotype of pAlb-hLPA-3’UTR-pA-TG/Apoe-KO male mice under chow diet conditions.
(A) The body weight (n=3-5); (B) Blood lipid profile (n=3-5); (C) Fasting blood glucose (n=3-5, Mean ± SEM, Unpaired t-test, *P<0.05, **P<0.01); (D) Oil Red O staining of aorta, the results indicated that after 24 weeks of CD, all male pAlb-hLPA-3’UTR-pA-TG/Apoe-KO mice and Apoe-KO mice exhibited significant lesions in the aorta (n=3-5, Mean ± SEM, Unpaired t-test, **P<0.01).
Fig2. In vivo drug efficiency of Olpasiran in pAlb-hLPA-3’UTR-pA-TG/Apoe-KO female mice under chow diet conditions.
pAlb- hLPA-3’UTR-pA-TG/Apoe-KO female mice were divided into two groups for the administration of PBS and Olpasiran (1 mpk) via subcutaneous injection. A total of two doses were administered at 13 weeks and 20 weeks of age, respectively. (A) The body weight change (n=3 for both G1 and G2 groups and n=4 for G3 groups, Mean ± SEM); (B) Fasting blood glucose (n=3-4, Mean ± SEM, Unpaired t-test, *P<0.05); (C) The level of serum human LPA levels after doses of PBS and Olpasiran (n=3 for PBS group and n=4 for Olpasiran group, Mean ± SEM, Unpaired t-test, *P<0.05, **P<0.01)
Fig.3 Phenotype of pAlb-hLPA-3’UTR-pA-TG/Apoe-KO male mice under western diet conditions (Sysebio, D12108C)
(A) The body weight (n=3-5); (B) Blood lipid profile (n=3-5, Mean ± SEM, Unpaired t-test, *P<0.05); (C) Oil Red O staining of aortic valve and aorta, the results indicated that all pAlb-hLPA-3’UTR-pA-TG/Apoe-KO mice and Apoe-KO mice (3/3) exhibited significant lipid accumulation in the aortic valves and significant lesions in the aorta at 12 weeks of WD. (n=3).
Abbr. WD, western diet.
Note. WD started at 6 weeks of age.
Fig.4 Phenotype of pAlb-hLPA-3’UTR-pA-TG/Apoe-KO female mice under western diet conditions.
(A) The body weight (n=3-5); (B) Blood lipid profile (n=3-5, Mean ± SEM, Unpaired t-test, *P<0.05); (C) Oil Red O staining of aortic valve and aorta, the results indicated that all pAlb-hLPA-3’UTR-pA-TG/Apoe-KO mice and Apoe-KO mice (3/3) exhibited significant lipid accumulation in the aortic valves and significant lesions in the aorta at 12 weeks of WD. (n=3).
Abbr. WD, western diet.
Note. WD started at 6 weeks of age.
You may also like
Workshop：Progress and Advances in Preclinical immuno-Oncology Research
SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.
Learn moreShanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreCustomizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!
At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
Learn more
