hCD3EDG/hCD22
Nomenclature
C57BL/6JSmo-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd22tm2(hCD22)Smoc
Cat. NO.
NM-XA-242719
Strain State
Repository Live
Model Description
Validation Data
Fig.1 Detection of CD22 expression on B cells in bone marrow and spleen of WT C57BL/6 mice and HO hCD3EDG/hCD22 mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 8 weeks old) and homozygous hCD3EDG/hCD22 humanized mice (male, 8 weeks old), and analyzed by flow cytometry with anti-mCD22 and anti-hCD22. hCD22 was exclusively detectable in hCD3EDG/hCD22 humanized mice but not in wild-type mice. hCD22 was exclusively detectable on B cells in hCD3EDG/hCD22 humanized mice, whereas mCD22 was exclusively detectable on B cells in wild-type C57BL/6 mice.
Abbr. HO, homozygous; WT, wild type.
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