Ighm/Ighd-KO

Nomenclature

C57BL/6JSmo-Ighmem1Ighdem1Smoc

Cat. NO.

NM-KO-200610

Strain State

Repository Live

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Model Description

Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans.
Research Application：Immune-related

Validation Data

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Fig1. Confirmation of Ighm knockout and B cell development in blood in Ighm/Ighd-KO mice by FACS.

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Fig2. T cell and NK cell lineages development in blood in Ighm/Ighd-KO mice by FACS.

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Fig3. In vivo anti-tumor efficacy in Ighm/Ighd-KO mice bearing MC38 syngeneic tumors.

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Fig4. The impact of B cell depeltion on the anti-tumor efficacy in Ighm/Ighd-KO mice bearing mPA6115 tumors (GEMM-derived homograft).

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