hSIRPA(2)

Nomenclature

C57BL/6JSmo-Sirpatm2(hSIRPA)Smoc

Cat. NO.

NM-HU-18015

Strain State

Repository Live

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Gene Summary

Gene Symbol
SIRPA

Model Description

The endogenous mouse Sirpa gene was replaced by human SIRPA gene . While hSIRPA (Stock No.NM-HU-00119) have been pulled from shelves for some reasons.
Research Application:Immunotherapy,drug screening

Validation Data

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Fig.1 Detection of hSIRPα expression on monocytes and neutrophils in blood of WT C57BL/6 mice and hSIRPA(2) mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 7 weeks old) and HO hSIRPA(2) humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hSIRPα and anti-mSIRPα. 

Abbr. HO, homozygous; WT, wild type.

0521c044-d919-4ca2-9e0e-08c35cef94a5.png

Fig.2 Detection of hSIRPα expression on dendritic cells and macrophages in Spleen of WT C57BL/6 mice and hSIRPA(2) mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 7 weeks old) and HO hSIRPA(2) humanized mice (male, 7 weeks old), and analyzed by flow cytometry with anti-hSIRPα and anti-mSIRPα. 

Abbr. HO, homozygous; WT, wild type.


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