hTREM2/5xFAD
Nomenclature
C57BL/6Smoc-Trem2em4(hTrem2)Tg(APPSwFlLon, PSEN1M146LL286V)6799Vas/Smoc
Cat. NO.
NMX-HU-232494
Strain State
Embryo Cryopreservation
Gene Summary
Gene Symbol
Trem2
Model Description
Validation Data
Fig.1 Detection of hTREM2 expression on microglia cells in brain of WT C57BL/6 mice and HO/HO hTREM2/5xFAD mice by FACS. Human TREM2 was detectable on a large part of microglia cells in hTREM2/5xFAD knockin mice but not in wild-type mice. Leukocytes were collected from wild-type C57BL/6 mice (male, 7 weeks old) and homozygous HO/HO hTREM2/5xFAD humanized mice (male, 29 weeks old), and analyzed by flow cytometry.
Abbr. HO, homozygous; WT, wild type.
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