H11-pAlb-hBAFF/hAPRIL

Nomenclature

C57BL/6JSmo-Igs2tm1(pAlb-hBAFF-pA)Tnfsf13tm(hTNFSF13)Smoc

Cat. NO.

NM-XA-252033

Strain State

Repository Live

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Model Description

The H11-pAlb-hBAFF (NM-KI-232137) was crossed with hAPRIL(NM-HU-220521) to generate H11-pAlb-hBAFF/hAPRIL mice.

Validation Data

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Fig.1 Detection of anti-mdsDNA IgG expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA.  Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male),  and analyzed by ELISA with mouse anti-dsDNA IgG-specific ELISA kit. Abbr.  HO, homozygous;  WT, wild type.

98302551-b7b7-4848-960a-ff58772dd2db.png

Fig.2 Detection of mouse IgA expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA. Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male), and analyzed by ELISA with anti-mIgA ELISA kit. Abbr.  HO, homozygous; WT, wild type.

Fig.5 Detection of mouse IgM expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA.  

Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male),  and analyzed by ELISA with anti-mIgM ELISA kit (Abclonal, RK00173).

Abbr.  HO, homozygous;  WT, wild type.

3feaf680-ed69-44df-8c98-636c123995d1.png

Fig.3 Detection of mouse IgE expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA. Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male),  and analyzed by ELISA with anti-mIgE ELISA kit. Abbr.  HO, homozygous;  WT, wild type.

86edecd6-7381-4a59-9587-4816006f267f.png

Fig.4 Detection of mouse IgG expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA. Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male), and analyzed by ELISA with anti-mIgG ELISA kit. Abbr.  HO, homozygous; WT, wild type.

16aa2c4d-960f-4036-8904-439b0d51cf59.png

Fig.5 Detection of mouse IgM expression in serum of C57BL/6 and H11-pAlb-hBAFF/hAPRIL mice by ELISA. Serum were collected from wild type C57BL/6 (male) and HO/HO H11-pAlb-hBAFF/hAPRIL mice (male),  and analyzed by ELISA with anti-mIgM ELISA kit. Abbr.  HO, homozygous;  WT, wild type.




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