hCCR6(2)
Nomenclature
C57BL/6JSmo-Ccr6tm2(hCCR6)Smoc
Cat. NO.
NM-HU-252534
Strain State
Repository Live
Gene Summary
Gene Symbol
Ccr6
Model Description
Validation Data
Fig.1 Detection of CCR6 expression in spleen and thymus by RT-PCR. Spleen and thymus RNA was extracted from 6-week-old female wild-type C57BL/6 (WT)(n=1) and homozygous hCCR6(2) knockin mice (HO) (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of hCCR6 and mCCR6 expression on CD19+ B cells in blood of WT C57BL/6 mice and hCCR6(2) mice by FACS. CD19+ B cells were collected from wild-type C57BL/6 mice (female, 10 weeks old) and hCCR6(2) humanized mice ((female, 9 and 10 weeks old), and analyzed by flow cytometry with anti-hCCR6 and anti-mCCR6.
Abbr. HO, homozygous; WT, wild type.
Fig.3 Detection of hCCR6 and mCCR6 expression on CD19+ B cells in spleen of WT C57BL/6 mice and hCCR6(2) mice by FACS. CD19+ B cells were collected from wild-type C57BL/6 mice (female, 10 weeks old) and hCCR6(2) humanized mice ((female, 9 and 10 weeks old), and analyzed by flow cytometry with anti-hCCR6 and anti-mCCR6.
Abbr. HO, homozygous; WT, wild type.
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