huHSC-(Kit-V831M NMG)
Nomenclature
huHSC-NOD.Cg-PrkdcscidIl2rgem1Kitem1(V831M)Smoc
Cat. NO.
NM-HU-263011
Strain State
Repository Live
Model Description
Validation Data
Fig 1. Body weight growth curves of NMG and Kit-V831M(NMG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(NMG) and NMG mice (n=12-18, female, 4 weeks). Prior to inoculation, NMG mice were irradiated with 1.0 Gy, whereas Kit-V831M (NMG) mice received no irradiation.
Fig 2. Survival rates of M-NSG and Kit-V831M(M-NSG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(M-NSG) and M-NSG mice (n=6-7, female, 4 weeks). Prior to inoculation, M-NSG mice were irradiated with 1.0 Gy, whereas Kit-V831M (M-NSG) mice received no irradiation.
Fig 3. Humanized immune reconstitution levels in NMG and Kit-V831M(NMG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(NMG) and NMG mice (n=12-18, female, 4 weeks). Prior to inoculation, NMG mice were irradiated with 1.0 Gy, whereas Kit-V831M (NMG) mice received no irradiation.
Fig 4. Humanized immune reconstitution levels in NMG and Kit-V831M(NMG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(NMG) and NMG mice (n=12-18, female, 4 weeks). Prior to inoculation, NMG mice were irradiated with 1.0 Gy, whereas Kit-V831M (NMG) mice received no irradiation.
Fig 5. Humanized immune reconstitution levels in NMG and Kit-V831M(NMG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(NMG) and NMG mice (n=12-18, female, 4 weeks). Prior to inoculation, NMG mice were irradiated with 1.0 Gy, whereas Kit-V831M (NMG) mice received no irradiation. At 26 weeks post immune reconstitution, bone marrow was collected from mice and human immune cell reconstitution levels were assessed by flow cytometry.
Fig 6. Humanized immune reconstitution levels in NMG and Kit-V831M(NMG) mice engrafted with human HSC. Human CD34+ HSCs (1E5) were intravenously injected into homozygous Kit-V831M(NMG) and NMG mice (n=12-18, female, 4 weeks). Prior to inoculation, NMG mice were irradiated with 1.0 Gy, whereas Kit-V831M (NMG) mice received no irradiation. At 26 weeks post immune reconstitution, lymph node tissue was collected from mice and human immune cell reconstitution levels were assessed by flow cytometry.
For strain background verification data, refer to Kit-V831M(NMG) NM-KI-242813. Click the link below for more details:
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