hCD3EDG/hBCMA/hCD38(2)

Nomenclature

C57BL/6JSmo-Tnfrsf17tm1(hBCMA)Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd38tm2(hCD38)Smoc

Cat. NO.

NM-XA-242724

Strain State

Repository Live

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Model Description

The hCD3EDG/hCD38(2)(NM-HU-220114) was crossed with hBCMA(NM-HU-200228) to generate hBCMA/hCD3EDG/hCD38 mice.

Validation Data

8ecf5386-27c5-4c6d-b11c-c6fef52648a0.png

Fig 1.Frequency of leukocyte subpopulations in the blood by flow cytometry

Blood was collected from WT C57BL/6 mice and HO hCD3EDG/hBCMA/hCD38(2)  mice (8-week-old, female, n=3). Flow cytometry analysis of frequencies of lymphocyte subpopulations in the blood. Bar indicated expressed as mean ± SEM.

Abbr.  HO, homozygous; WT, wild type.

6d19f438-71f6-4ba8-b196-14e3916dfea2.png

Fig 2.Frequency of leukocyte subpopulations in the blood by flow cytometry

Blood was collected from WT C57BL/6 mice and HO hCD3EDG/hBCMA/hCD38(2)  mice (8-week-old, male, n=3). Flow cytometry analysis of frequencies of lymphocyte subpopulations in the blood. Bar indicated expressed as mean ± SEM.

Abbr.  HO, homozygous; WT, wild type.

40cb592a-1ec5-4482-882a-e155f22833ba.png

Fig 3.Frequency of leukocyte and myeloid subpopulations in the spleen by flow cytometry

Spleen was collected from WT C57BL/6 mice and HO hCD3EDG/hBCMA/hCD38(2)  mice (8-week-old, male, n=3). Flow cytometry analysis of frequencies of (A) lymphocyte and (B) myeloid subpopulations in the spleen. Bar indicated expressed as mean ± SEM.

Abbr.  HO, homozygous; WT, wild type.

619f8c29-e402-49ed-8854-fdbab271c4a0.png

Fig 4.Frequency of leukocyte and myeloid subpopulations in the spleen by flow cytometry

Spleen was collected from WT C57BL/6 mice and HO hCD3EDG/hBCMA/hCD38(2)  mice (8-week-old, female, n=3). Flow cytometry analysis of frequencies of (A) lymphocyte and (B) myeloid subpopulations in the spleen. Bar indicated expressed as mean ± SEM.

Abbr.  HO, homozygous; WT, wild type.


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