SmocMab^® Fully Humanized Antibody Mice

SmocMab^® fully humanized antibody mice employ large-fragment gene sequence replacement technology to integrate the human antibody variable region gene library into the endogenous loci of mice. This approach achieves full humanization of the variable region while preserving close-to-wild-type immune response capabilities, delivering a broader spectrum of immune responses and enabling the successful production of large quantities of high-affinity fully humanized antibodies to accelerate therapeutic antibody drug development.

The SmocMab^® fully humanized antibody mouse series comprises three models for different antibody R&D needs: a standard IgG humanized mouse model for conventional antibody development, a heavy-chain-only humanized mouse model dedicated to nanobody discovery, and a common light chain IgG humanized mouse model for bispecific and multispecific antibody development.